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Review
. 2010 Jan;125(1):4-13; quiz 14-5.
doi: 10.1016/j.jaci.2009.11.027.

Recent insights into atopic dermatitis and implications for management of infectious complications

Mark Boguniewicz  1 , Donald Y M Leung
Affiliations
Review

Recent insights into atopic dermatitis and implications for management of infectious complications

Mark Boguniewicz et al. J Allergy Clin Immunol. 2010 Jan.

Abstract

Atopic dermatitis (AD) is a common complex disease that frequently follows a chronic relapsing course and affects the quality of life of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Patients with AD have a unique predisposition to colonization or infection by a number of microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. A multipronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes.

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Figures

Figure 1a
Figure 1a
Child with atopic dermatitis superinfected with toxin secreting Staphylococcus aureus.
Fig 1b
Fig 1b
Child with atopic dermatitis with course complicated by eczema herpeticum.
See this image and copyright information in PMC

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References

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