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Comment
. 2010 Jan 29;327(5965):528-9.
doi: 10.1126/science.1185869.

Immunology. Arsonists in rheumatoid arthritis

Guy A Zimmerman  1 , Andrew S Weyrich
Affiliations
Comment

Immunology. Arsonists in rheumatoid arthritis

Guy A Zimmerman et al. Science. .

Abstract

Inflammation associated with rheumatoid arthritis is stoked by platelets, expanding their roles into the immune system.

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Figures

Figure
Figure. Perpetrators in a painful joint
In rheumatoid arthritis, the joint synovium becomes inflamed with dilated blood vessels and immune cells. Polymorphonuclear leukocytes (PMN), cytokines, chemokines, and other mediators of inflammation, accumulate in the synovial fluid. Local activation of platelets by collagen and synoviocytes may trigger the release of microparticles from platelets. These microparticles then enter the joint space and further amplify inflammation by producing interleukin-1. This then activates synoviocytes, thus supporting a cycle of inflammation.
See this image and copyright information in PMC

Comment on

References

    1. Boilard E, et al. Science. 2010;327:580. - PMC - PubMed
    1. Perez-Pujol S, et al. Cytometry A. 2007;71:38. - PubMed
    1. Denis MM, et al. Cell. 2005;122:379. - PMC - PubMed
    1. Rosenberg AE. In: Robbins and Cotran Pathologic Basis of Disease. 8. Kumar V, Abbas AK, Favsto N, Aster JC, editors. Saunders; Philadelphia: 2010. pp. 1205–1256.
    1. Choy EH, Panayi GS. N Engl J Med. 2001;344:907. - PubMed