Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010;29(1):75-81.
doi: 10.1159/000264630. Epub 2010 Jan 28.

Volume loss of the medial temporal lobe structures in subjective memory impairment

Nadine Striepens  1 , Lukas Scheef, Andrea Wind, Julius Popp, Annika Spottke, Déirdre Cooper-Mahkorn, Husam Suliman, Michael Wagner, Hans H Schild, Frank Jessen
Affiliations
Free article

Volume loss of the medial temporal lobe structures in subjective memory impairment

Nadine Striepens et al. Dement Geriatr Cogn Disord. 2010.
Free article

Abstract

Background/aims: Subjective memory impairment (SMI) has been suggested as a manifestation of Alzheimer's Disease (AD) preceding mild cognitive impairment (MCI). In this study, we determined the volumes of the hippocampus, the entorhinal cortex (EC) and the amygdala to provide biological evidence for AD in SMI.

Methods: Regional volumetric measures were manually traced on 3-Tesla MRI scans.

Results: Total brain volume did not differ between the groups. Individuals with SMI had reduced volumes of the hippocampus bilaterally (right p = 0.001; left p < 0.001), the bilateral EC (right p = 0.031, left p = 0.006) and the right amygdala (p = 0.01) compared to the control group.

Conclusion: Volume reduction of bilateral hippocampus, bilateral EC and right amygdala supports the concept of SMI as a very early manifestation of AD prior to MCI. SMI may indicate awareness of a degenerative process that can still be functionally compensated.

PubMed Disclaimer

Publication types

Substances