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Case Reports
. 2010 Feb;6(2):117-23.
doi: 10.1038/nrneph.2009.215.

Hyponatremia and seizures caused by triamcinolone-induced adrenal insufficiency

Stefan Reuter  1 , Niklas Scholten, Hermann Pavenstädt, Uta Hillebrand, Eckhart Büssemaker
Affiliations
Case Reports

Hyponatremia and seizures caused by triamcinolone-induced adrenal insufficiency

Stefan Reuter et al. Nat Rev Nephrol. 2010 Feb.

Erratum in

  • Nat Rev Nephrol. 2010 Jun;6(6):316

Abstract

Background: A 49-year-old woman presented to hospital with an 18-month history of hyponatremic episodes, nausea, vomiting, anorexia and fatigue.

Investigations: Physical examination, laboratory tests including full blood count, measurement of electrolytes, hormones, autoantibodies, thyroid and renal function, corticotropin-releasing-hormone stimulation test, 24 h urinalysis and abdominal ultrasonography.

Diagnosis: Severe symptomatic hyponatremia in a patient with secondary adrenal insufficiency caused by treatment of lumbago with triamcinolone injections.

Management: Hydrocortisone replacement therapy (15 mg daily) for 3 months, followed by a tapering schedule over 12-24 months.

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