Henoch-Schönlein purpura in children from western Turkey: a retrospective analysis of 430 cases

Abstract

The medical records of children discharged with a diagnosis of Henoch-Schönlein purpura (HSP) between January 1996 and March 2006 were analyzed retrospectively. The patient population consisted of 430 children (225 boys, mean age: 7.9 +/- 2.9 years; range: 2-14 years). At onset, purpura was present in all cases, arthritis/arthralgias in 195 (45.3%), abdominal involvement in 148 (34.4%), and renal involvement in 192 (44.7%). Purpura manifested after 24 hours of admittance in 64 patients (14.9%) (atypical cases). Multivariate analysis showed that female sex, atypical presentation and early corticosteroid treatment increased the risk of renal involvement (p<0.05). Recurrences, occurring in 22 (5.2%) patients, were correlated with early corticosteroid treatment (p < 0.05). After a mean 17.3 +/- 2.9 months of follow-up, no patient had renal insufficiency. Female sex, atypical presentation and early corticosteroid treatment were considered to increase the risk of developing renal involvement, and relapses occurred more frequently in children treated with corticosteroid. Our study confirmed that HSP is generally a benign disease in children from western Turkey.