Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Feb;16(2):297-300.
doi: 10.3201/eid1602.081707.

Bordetella pertussis clones identified by multilocus variable-number tandem-repeat analysis

Jacob Kurniawan  1 , Ram P Maharjan, Wai Fong Chan, Peter R Reeves, Vitali Sintchenko, Gwendolyn L Gilbert, Frits R Mooi, Ruiting Lan
Affiliations

Bordetella pertussis clones identified by multilocus variable-number tandem-repeat analysis

Jacob Kurniawan et al. Emerg Infect Dis. 2010 Feb.

Abstract

Multilocus variable-number tandem-repeat analysis (MLVA) of 316 Bordetella pertussis isolates collected over 40 years from Australia and 3 other continents identified 66 MLVA types (MTs), including 6 predominant MTs. Typing of genes encoding acellular vaccine antigens showed changes that may be vaccine driven in 2 MTs prevalent in Australia.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Temporal trends of predominant multilocus variable-number tandem-repeat analysis (MLVA) types in Australia. Isolates of 4 major MLVA types (MT70, MT27, MT29, and MT64) obtained in Australia were divided into 3 periods: whole cell vaccine (WCV) (before 1997), transition from WCV to acellular vaccine (ACV) (1997–1999), and ACV (2000 onward).
Figure 2
Figure 2
Minimum spanning tree (MST) of multilocus variable-number tandem-repeat analysis (MLVA types for global Bordetella pertussis isolates. The MST produced in Bionumerics (Applied Maths, Kortrijk, Belgium) used categorical coefficient and the eBURST priority rule of the highest number of single-locus changes for the clustering. Each circle represents an MLVA type with the type number in the circle. Thick lines, types differing by a single MLVA locus; thin lines, double-locus variants; dotted lines, 2 types differing by >2 MLVA loci. The size of the circle reflects the number of isolates with a given MLVA type. The color codes for country of origin are shown, and pie charts within a circle are used to indicate the
proportion of isolates.
See this image and copyright information in PMC

References

    1. Tan T, Trindade E, Skowronski D. Epidemiology of pertussis. Pediatr Infect Dis J. 2005;24:S10–8. 10.1097/01.inf.0000160708.43944.99 - DOI - PubMed
    1. Guris D, Strebel PM, Bardenheier B, Brennan M, Tachdjian R, Finch E, et al. Changing epidemiology of pertussis in the United States: increasing reported incidence among adolescents and adults, 1990–1996. Clin Infect Dis. 1999;28:1230–7. 10.1086/514776 - DOI - PubMed
    1. Celentano LPMDM, Massari MD, Paramatti DD, Salmaso SD, Tozzi AE. EUVAC-NET Group. Resurgence of pertussis in Europe. Pediatr Infect Dis J. 2005;24:761–5. 10.1097/01.inf.0000177282.53500.77 - DOI - PubMed
    1. Poynten M, McIntyre PB, Mooi FR, Heuvelman KJ, Gilbert GL. Temporal trends in circulating Bordetella pertussis strains in Australia. Epidemiol Infect. 2004;132:185–93. 10.1017/S095026880300164X - DOI - PMC - PubMed
    1. Bamberger ES, Srugo I. What is new in pertussis? Eur J Pediatr. 2008;167:133–9. 10.1007/s00431-007-0548-2 - DOI - PMC - PubMed

Publication types

LinkOut - more resources