A history of bone marrow transplantation
- PMID: 20113883
- DOI: 10.1016/j.iac.2009.11.005
A history of bone marrow transplantation
Abstract
The last 40 years has seen the emergence of hematopoietic stem cell transplantation as a therapeutic modality for fatal diseases and as a curative option for individuals born with inherited disorders that carry limited life expectancy and poor quality of life. Despite the rarity of many primary immunodeficiency diseases, these disorders have led the way toward innovative therapies and further provide insights into mechanisms of immunologic reconstitution applicable to all hematopoietic stem cell transplants. This article represents a historical perspective of the early investigators and their contributions. It also reviews the parallel work that oncologists and immunologists have undertaken to treat both primary immunodeficiencies and hematologic malignancies.
Copyright 2010 Elsevier Inc. All rights reserved.
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A history of bone marrow transplantation.Hematol Oncol Clin North Am. 2011 Feb;25(1):1-15. doi: 10.1016/j.hoc.2010.11.001. Hematol Oncol Clin North Am. 2011. PMID: 21236386
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