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Review
. 2010 Feb;30(1):1-15.
doi: 10.1016/j.iac.2009.11.005.

A history of bone marrow transplantation

M Teresa de la Morena  1 , Richard A Gatti
Affiliations
Review

A history of bone marrow transplantation

M Teresa de la Morena et al. Immunol Allergy Clin North Am. 2010 Feb.

Abstract

The last 40 years has seen the emergence of hematopoietic stem cell transplantation as a therapeutic modality for fatal diseases and as a curative option for individuals born with inherited disorders that carry limited life expectancy and poor quality of life. Despite the rarity of many primary immunodeficiency diseases, these disorders have led the way toward innovative therapies and further provide insights into mechanisms of immunologic reconstitution applicable to all hematopoietic stem cell transplants. This article represents a historical perspective of the early investigators and their contributions. It also reviews the parallel work that oncologists and immunologists have undertaken to treat both primary immunodeficiencies and hematologic malignancies.

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Republished in

  • A history of bone marrow transplantation.
    de la Morena MT, Gatti RA. de la Morena MT, et al. Hematol Oncol Clin North Am. 2011 Feb;25(1):1-15. doi: 10.1016/j.hoc.2010.11.001. Hematol Oncol Clin North Am. 2011. PMID: 21236386

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