Comment
doi: 10.1016/j.chom.2010.01.002.
Hemozoin: malaria's "built-in" adjuvant and TLR9 agonist
Affiliations
- PMID: 20114022
- DOI: 10.1016/j.chom.2010.01.002
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Comment
Hemozoin: malaria's "built-in" adjuvant and TLR9 agonist
Cell Host Microbe.
.
Abstract
The "built-in" adjuvant in a whole-microbe vaccine potentially triggers protective immunity. Coban et al. now demonstrate that crude blood stage extract of the malaria parasite Plasmodium falciparum drives parasite-specific immune responses via Hemozoin, a byproduct of heme detoxification, functioning as a TLR9 agonist and, therefore, as a "built-in" adjuvant.
2010 Elsevier Inc. All rights reserved.
Comment on
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Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9.Cell Host Microbe. 2010 Jan 21;7(1):50-61. doi: 10.1016/j.chom.2009.12.003. Cell Host Microbe. 2010. PMID: 20114028