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Review
. 2010 Jul;86 Suppl 1(Suppl 1):7-12.
doi: 10.1016/j.earlhumdev.2010.01.012. Epub 2010 Jan 29.

Risk factors and prevention of late-onset sepsis in premature infants

L Corbin Downey  1 , P Brian Smith, Daniel K Benjamin Jr
Affiliations
Review

Risk factors and prevention of late-onset sepsis in premature infants

L Corbin Downey et al. Early Hum Dev. 2010 Jul.

Abstract

Late-onset sepsis in premature infants is a major cause of morbidity, mortality, and increased medical costs. Risk factors include low birth weight, low gestational age, previous antimicrobial exposure, poor hand hygiene, and central venous catheters. Methods studied to prevent late-onset sepsis include early feedings, immune globulin administration, prophylactic antimicrobial administration, and improved hand hygiene. In this review, we will outline the risk factors for development of late-onset sepsis and evidence supporting methods for prevention of late-onset sepsis in premature infants.

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Figures

Figure 1
Figure 1
Survival after a blood culture [6]
Figure 2
Figure 2
Positive blood cultures over the first 50 days of life by gestational age group [14].
Figure 2
Figure 2
Positive blood cultures over the first 50 days of life by gestational age group [14].
Figure 2
Figure 2
Positive blood cultures over the first 50 days of life by gestational age group [14].
Figure 3
Figure 3
Burden of proof required to institute therapy.
See this image and copyright information in PMC

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