Review
doi: 10.1016/j.micres.2009.11.006.
Epub 2010 Jan 29.
Limitations in doxorubicin production from Streptomyces peucetius
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- PMID: 20116225
- DOI: 10.1016/j.micres.2009.11.006
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Review
Limitations in doxorubicin production from Streptomyces peucetius
Microbiol Res.
.
Free article
Abstract
Doxorubicin (DXR), produced by Streptomyces peucetius ATCC 27952, exhibits potent antitumor activity against various cancer cell lines. Considerable time has lapsed since the biosynthesis of DXR and its overproduction was first summarized. Based on biosynthetic studies and product analysis, various factors affecting its production by the parental strain, S. peucetius ATCC 27952, are reviewed to better circumvent any bottlenecks in DXR production, thereby providing ideas to genetically engineered industrial strains of S. peucetius.
Copyright 2009 Elsevier GmbH. All rights reserved.
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