[Efficacy of atazanavir in treatment-naive patients]

Abstract

The characteristics of atazanavir (convenient doses, good tolerance, and excellent lipid profile) makes it an attractive drug to be included in initial regimes. Clinical trials have been performed on patients with no previous antiretroviral treatment, either atazanavir without boost (400 mg once per day) or atazanavir boosted with ritonavir (400/100 mg). Although atazanavir without boost is effective, there is a tendency for a higher number of failures and a higher development of resistant mutations than in patients who fail with boosted atazanavir. Therefore, it is recommended to use boosted atazanavir in patients that start on treatment. In clinical studies, boosted atazanavir can be used with any nucleoside analogue. No pharmacokinetic or pharmacodynamic interaction problems have been detected with the two nucleoside combinations at fixed doses (tenofovir/FTC, abacavir/3TC). Randomised clinical studies have been carried out that compared atazanavir with other boosted protease inhibitors. In the comparative study with lopinavir/ritonavir administered two times a day, atazanavir/ritonavir once per day demonstrated noninferiority, with a similar efficacy regardless of the patient baseline viral load. The atazanavir/ritonavir virological efficacy did not appear to be affected by the baseline immunological status of the patients, which did influence the lopinavir/ritonavir response. Atazanavir/ritonavir is a useful drug combination in the initial treatment of HIV infected adult patients. Its increased virological and immunological efficacy, together with its ease of administration, good tolerance and excellent lipid profile makes it a PI of choice in these patients.