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. 2010 Apr;45(4):1524-8.
doi: 10.1016/j.ejmech.2009.12.061. Epub 2010 Jan 14.

Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma

Cedric S Graebin  1 , Maria de F Madeira, Jenicer K U Yokoyama-Yasunaka, Danilo C Miguel, Silvia R B Uliana, Diego Benitez, Hugo Cerecetto, Mercedes González, Ricardo Gomes da Rosa, Vera Lucia Eifler-Lima
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Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma

Cedric S Graebin et al. Eur J Med Chem. 2010 Apr.

Abstract

The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than the standard drug pentamidine. Additionally, we have identified two promising new anti-T. cruzi limonene derivatives.

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