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. 2010 Mar 30;220(1-2):120-4.
doi: 10.1016/j.jneuroim.2010.01.003. Epub 2010 Feb 1.

MGAT5 alters the severity of multiple sclerosis

B Brynedal  1 , J Wojcik, F Esposito, V Debailleul, J Yaouanq, F Martinelli-Boneschi, G Edan, G Comi, J Hillert, H Abderrahim
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MGAT5 alters the severity of multiple sclerosis

B Brynedal et al. J Neuroimmunol. .

Abstract

Multiple Sclerosis (MS) is a genetically complex immune mediated, demyelinating disease of the central nervous system. To date no genetic variants have been unambiguously linked to disease severity. We have conducted a genome wide screen, using Affymetrix Genechip 500K technology, for severity in 1040 MS patients. Two markers within MGAT5, a gene coding for a glycosylation enzyme, were found to be significantly associated with outcome in the screening as well as in an independent population (combined p-values: 2.8 x 10(-6) and 1.5 x 10(-7)).

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