Review
doi: 10.1253/circj.cj-09-1021.
Epub 2010 Jan 30.
Role of the SDF-1/CXCR4 system in myocardial infarction
Affiliations
- PMID: 20118565
- DOI: 10.1253/circj.cj-09-1021
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Review
Role of the SDF-1/CXCR4 system in myocardial infarction
Circ J.
2010 Mar.
Free article
Abstract
Myocardial infarction (MI) is accompanied by an inflammatory response, leading to the recruitment of leukocytes and subsequent myocardial injury and healing. Chemokines are potent chemoattractant cytokines that regulate leukocyte trafficking in inflammatory processes. Recent evidence indicates that chemokines play a role not only in leukocyte trafficking but also in angiogenesis and cardioprotection. In particular, stromal cell-derived factor-1alpha (SDF-1alpha) has generated considerable interest for its role in the pathophysiology of MI. This review will focus on the role of SDF-1 and its receptor CXC chemokine receptor 4 (CXCR4; ie, the SDF-1/CXCR4 system) in the pathophysiology of MI and discuss their potential as therapeutic targets for MI.
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