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Review
. 2010 Feb;9(2):107-15.
doi: 10.1038/nrd3055.

Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases

Yihai Cao  1
Affiliations
Review

Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases

Yihai Cao. Nat Rev Drug Discov. 2010 Feb.

Abstract

Current pharmacotherapeutic options for treating obesity and related metabolic disorders remain limited and ineffective. Emerging evidence shows that modulators of angiogenesis affect the expansion and metabolism of fat mass by regulating the growth and remodelling of the adipose tissue vasculature. Pharmacological manipulation of adipose tissue neovascularization by angiogenic stimulators and inhibitors might therefore offer a novel therapeutic option for the treatment of obesity and related metabolic disorders. This Perspective discusses recent progress in understanding the molecular mechanisms that control adipose tissue angiogenesis and in defining potential new vascular targets and approaches for the treatment of this group of diseases.

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References

    1. Trends Mol Med. 2001 Sep;7(9):401-7 - PubMed
    1. N Engl J Med. 2006 Oct 5;355(14):1419-31 - PubMed
    1. Science. 2005 Jan 21;307(5708):373-5 - PubMed
    1. Diabetes. 2007 Apr;56(4):901-11 - PubMed
    1. Cell. 1997 Jan 24;88(2):277-85 - PubMed

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