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. 2010 Feb;12(2):104-6.
doi: 10.1038/ncb0210-104.

Mitochondria get a Parkin' ticket

Philipp Wild  1 , Ivan Dikic
Affiliations

Mitochondria get a Parkin' ticket

Philipp Wild et al. Nat Cell Biol. 2010 Feb.

Abstract

Recent studies have revealed a prominent role of mitochondrial dysfunction in the development of one of the most common neurodegenerative disorders, Parkinson's disease. The ubiquitin ligase Parkin and the protein kinase PINK1, whose mutations are associated with Parkinson's disease, function in a pathway that links ubiquitylation with selective autophagy of damaged mitochondria.

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