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. 2009 Sep;65(3):305-12.
doi: 10.1007/BF03180583.

Brain mitochondrial alterations after chronic alcohol consumption

I Almansa  1 , A Fernández, C García-Ruiz, M Muriach, J M Barcia, M Miranda, J C Fernández-Checa, F J Romero
Affiliations

Brain mitochondrial alterations after chronic alcohol consumption

I Almansa et al. J Physiol Biochem. 2009 Sep.

Abstract

The aim of this study was to demonstrate the existence of alterations in glutathione and cholesterol homeostasis in brain mitochondria from alcoholic rats. Glutathione concentration decreased, whereas oxidized glutathione and cholesterol contents increased in these organelles, suggesting the ethanol-induced generation of reactive oxygen species, and the impairment of mitochondrial uptake of glutathione, possibly due to the increase in cholesterol deposition. The release of apoptogenic proteins was increased after stimulating mitochondria from the brain of alcoholic rats with atractyloside. As a conclusion, chronic alcohol consumption might sensitize brain mitochondria to apoptotic stimuli, and promote the subsequent release of apoptotic proteins.

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References

    1. Cell Death Differ. 2003 Oct;10(10):1148-55 - PubMed
    1. Ann Hepatol. 2003 Apr-Jun;2(2):69-75 - PubMed
    1. Oncogene. 2001 Jul 19;20(32):4305-16 - PubMed
    1. Gastroenterology. 2002 Jun;122(7):2049-63 - PubMed
    1. Int J Neurosci. 2003 Dec;113(12):1643-52 - PubMed

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