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Review
. 2010;12(1):101.
doi: 10.1186/ar2894. Epub 2010 Jan 20.

Identity of mysterious CD4+CD25-Foxp3+ cells in SLE

David A Horwitz
Review

Identity of mysterious CD4+CD25-Foxp3+ cells in SLE

David A Horwitz. Arthritis Res Ther. 2010.

Abstract

Various abnormalities in CD4+CD25+ regulatory T cells (Tregs) in systemic lupus erythematosus (SLE) include increased Foxp3+ cells that are CD25 negative. Barring methodological technical factors, these cells could be atypical Tregs or activated non-Treg CD4+ cells that express Foxp3. Two groups have reached opposite conclusions that could possibly reflect the subjects studied. One group studied untreated new-onset SLE and suggested that these T cells were mostly CD25-Foxp3+ non-Tregs. The other group studied patients with long-standing disease and suggested that these cells are mostly dysfunctional Tregs. A third group reported increased Foxp3+CD4+CD25dim rather than CD25- cells in active SLE and these were also non-Tregs. Thus, it is likely that not all Foxp3+ T cells in SLE have protective suppressive activity.

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