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Comment
. 2010 Jan 29;37(2):153-5.
doi: 10.1016/j.molcel.2010.01.010.

WT1 the oncogene: a tale of death and HtrA

Abdelkader Essafi  1 , Nicholas D Hastie
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WT1 the oncogene: a tale of death and HtrA

Abdelkader Essafi et al. Mol Cell. .
Free article

Abstract

Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.

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