Review
doi: 10.1016/j.dnarep.2010.01.005.
Epub 2010 Feb 1.
FANCJ: solving problems in DNA replication
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- PMID: 20122882
- DOI: 10.1016/j.dnarep.2010.01.005
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Review
FANCJ: solving problems in DNA replication
DNA Repair (Amst).
.
Abstract
The FANCJ protein (also known as BACH1 and BRIP1) is a DNA helicase that is required to preserve the genetic and structural integrity of the genome in complex eukaryotes. In humans, mutations in FANCJ are associated with the chromosome instability disorder Fanconi's anemia and also with the inherited predisposition early-onset breast cancer. Here I will discuss the contribution of FANCJ to human disease, its role in maintenance of genome stability and some current thoughts on the mechanisms through which this is achieved.
(c) 2010 Elsevier B.V. All rights reserved.
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