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. 2010 Feb;6(2):72-3.
doi: 10.1038/nrrheum.2009.276.

Epidemiology: Interpreting studies of interactions between RA risk factors

Elizabeth W Karlson  1 , Karen H Costenbader
Affiliations

Epidemiology: Interpreting studies of interactions between RA risk factors

Elizabeth W Karlson et al. Nat Rev Rheumatol. 2010 Feb.

Abstract

Interactions between HLA and PTPN22 genotypes and smoking have been implicated in overall susceptibility to rheumatoid arthritis as well as the incidence of particular disease phenotypes in case-control and case-only studies. As recent epidemiological evidence shows, deciphering these interactions demands consideration of the analytical approach used.

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References

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