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. 2009 Fall;11(Suppl 1):S19-25.

Medical management of lower urinary tract symptoms

Eric E Laborde  1 , Kevin T McVary
Affiliations

Medical management of lower urinary tract symptoms

Eric E Laborde et al. Rev Urol. 2009 Fall.

Abstract

Lower urinary tract symptoms (LUTS) are a common complaint among aging men and are often caused by benign prostatic hyperplasia (BPH). A number of medical treatments for LUTS/BPH exist, such as alpha-blockers, 5alpha-reductase inhibitors, anticholinergics, phosphodiesterase type 5 (PDE5) inhibitors, and combination therapies. Agonist binding of the alpha(1A)-adrenergic receptor (AR), causing prostatic smooth muscle contraction, has been attributed to cause some LUTS. Therefore, medical therapy has aimed to block the alpha(1A)-AR and improve LUTS. Determining which therapy to choose must take into account individual patient factors as well as cost and patient choice.

Keywords: 5α-reductase inhibitors; Anticholinergics; Benign prostatic hyperplasia; Combination therapy; Lower urinary tract symptoms; Phosphodiesterase type 5 inhibitors; α-Blockers.

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Figures

Figure 1
Figure 1
α and β adrenergic receptor (AR) subdivisions.
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References

    1. Berry SJ, Coffey DS, Walsh PC, Ewing LL. The development of human benign prostatic hyperplasia with age. J Urol. 1984;132:474–479. - PubMed
    1. Price DT, Lefkowitz RJ, Caron MG, et al. Localization of mRNA for three distinct alpha 1-adrenergic receptor subtypes in human tissues: implications for human alpha-adrenergic physiology. Mol Pharmacol. 1994;45:171–175. - PubMed
    1. Malloy BJ, Price DT, Price RR, et al. Alpha1-adrenergic receptor subtypes in human detrusor. J Urol. 1998;160:937–943. - PubMed
    1. Lepor H, Tang R, Shapiro E. The alphaadrenoceptor subtype mediating the tension of human prostatic smooth muscle. Prostate. 1993;22:301–307. - PubMed
    1. McConnell JD, Roehrborn CG, Bautista OM, et al. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N Engl J Med. 2003;349:2387–2398. - PubMed

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