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. 2011 Mar;28(1):237-40.
doi: 10.1007/s12032-010-9432-4. Epub 2010 Feb 2.

Osteolytic lesions marker in multiple myeloma

Irena Djunic  1 , Ivo Elezovic, Milica Marinkovic, Nada Suvajdzic-Vukovic, Dragica Tomin, Gradimir Jankovic, Jelena Bila, Darko Antic, Ana Vidovic, Borka Neskovic, Dragica Nikolic-Vukosavljevic
Affiliations

Osteolytic lesions marker in multiple myeloma

Irena Djunic et al. Med Oncol. 2011 Mar.

Abstract

The degradation product of collagen type I carboxy terminal telopeptide (ICTP) represents a new biochemical parameter that reflects the changes in the resorption properties of skeletal system. Affection of the skeleton is one of the most important characteristics of multiple myeloma (MM). We estimated significance of ICTP as osteolysis predictor and overall survival in comparison with standard prognostic parameters β(2)-microglobulin and C-reactive protein (CRP), in patients with MM. With our results, we have shown significant difference in serum level of ICTP (P = 0.009) between patients with and without osteolysis on conventional radiography. It was proved that ICTP is the most significant predictor of osteolysis (P = 0.09), while CRP is the most significant risk factor for overall survival (P < 0.01). Being highly significant predictor of osteolysis, ICTP can be used for identification of patients with MM who had increased risk for developing osteolytic lesions.

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References

    1. Br J Haematol. 2000 Apr;109(1):24-9 - PubMed
    1. Clin Cancer Res. 2003 Aug 1;9(8):3047-51 - PubMed
    1. Br J Haematol. 1990 Dec;76(4):484-7 - PubMed
    1. Clin Biochem. 1997 Dec;30(8):573-93 - PubMed
    1. Eur J Haematol. 2000 Feb;64(2):121-9 - PubMed