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Review
. 2010 Feb 3:7:10.
doi: 10.1186/1742-2094-7-10.

Role of platelets in neuroinflammation: a wide-angle perspective

Lawrence L Horstman  1 , Wenche Jy, Yeon S Ahn, Robert Zivadinov, Amir H Maghzi, Masoud Etemadifar, J Steven Alexander, Alireza Minagar
Affiliations
Review

Role of platelets in neuroinflammation: a wide-angle perspective

Lawrence L Horstman et al. J Neuroinflammation. .

Abstract

Objectives: This review summarizes recent developments in platelet biology relevant to neuroinflammatory disorders. Multiple sclerosis (MS) is taken as the "Poster Child" of these disorders but the implications are wide. The role of platelets in inflammation is well appreciated in the cardiovascular and cancer research communities but appears to be relatively neglected in neurological research.

Organization: After a brief introduction to platelets, topics covered include the matrix metalloproteinases, platelet chemokines, cytokines and growth factors, the recent finding of platelet PPAR receptors and Toll-like receptors, complement, bioactive lipids, and other agents/functions likely to be relevant in neuroinflammatory diseases. Each section cites literature linking the topic to areas of active research in MS or other disorders, including especially Alzheimer's disease.

Conclusion: The final section summarizes evidence of platelet involvement in MS. The general conclusion is that platelets may be key players in MS and related disorders, and warrant more attention in neurological research.

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References

    1. McNicol A, Israels SJ. Beyond hemostasis: the role of platelets in inflammation, malignancy and infection. Cardiovasc Hematol Disord Drug Targets. 2008;8:99–117. doi: 10.2174/187152908784533739. - DOI - PubMed
    1. Martin JF, Levine RP. In: The Platelet in Health and Disease. Page CP, editor. London Blackwell Scientific; 1991. Evidence in favor of the lungs and against the bone marrow as the site of platelet production.
    1. Aarts PA, vandenBroek SA, Prins GW, Kuiken GD, Sixma JJ, Heethaar RM. Blood platelets are concentrated near the wall and red cells in the center in flowing blood. Arteriosclerosis. 1985;8:819–24. - PubMed
    1. Jy W, Jimenez JJ, Horstman LL, Ahn YS. In: Interventional Cardiology Secrets. Marchena Ed, Ferrara A, editor. NY London Elsevier Press; 2003. Platelets, coagulation and thrombosis. Ch. 8; pp. 42–50.
    1. Gresele P, Falcinelli E, Momi S. Potentiation and priming of platelet activation: a potential target for antiplatelet therapy. Trends Pharm Sci. 2008;29:352–60. doi: 10.1016/j.tips.2008.05.002. - DOI - PubMed

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