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Review
. 2010 Jan 19;17(1):1-3.
doi: 10.1016/j.ccr.2009.12.033.

HELP for AML: methylation profiling opens new avenues

Lars Bullinger  1 , Scott A Armstrong
Affiliations
Free article
Review

HELP for AML: methylation profiling opens new avenues

Lars Bullinger et al. Cancer Cell. .
Free article

Abstract

There is growing evidence that aberrant gene expression in cancer is linked to epigenetic deregulation like promoter cytosine methylation in CpG-islands. In this issue of Cancer Cell, Figueroa et al. show that genome-wide promoter DNA methylation profiling reveals unique AML subgroups and methylation patterns that are associated with clinical outcome.

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