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. 2010 Jan 19;17(1):7-9.
doi: 10.1016/j.ccr.2009.12.031.

IDH1 mutations in gliomas: when an enzyme loses its grip

Christian Frezza  1 , Daniel A Tennant, Eyal Gottlieb
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Free article

IDH1 mutations in gliomas: when an enzyme loses its grip

Christian Frezza et al. Cancer Cell. .
Free article

Abstract

The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studying isocitrate dehydrogenase (IDH) mutations since their discovery just over a year ago. In a recent study published in Nature, Dang et al. identified 2-hydroxyglutarate as a product of tumor-associated IDH mutants with potential oncogenic activities.

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