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Review
. 2010 Apr:125 Suppl 1:S23-5.
doi: 10.1016/j.thromres.2010.01.027. Epub 2010 Feb 4.

Protein-phospholipid interactions in blood clotting

James H Morrissey  1 , Rebecca L Davis-Harrison, Narjes Tavoosi, Ke Ke, Vincent Pureza, John M Boettcher, Mary C Clay, Chad M Rienstra, Y Zenmei Ohkubo, Taras V Pogorelov, Emad Tajkhorshid
Affiliations
Review

Protein-phospholipid interactions in blood clotting

James H Morrissey et al. Thromb Res. 2010 Apr.

Abstract

Most steps of the blood clotting cascade require the assembly of a serine protease with its specific regulatory protein on a suitable phospholipid bilayer. Unfortunately, the molecular details of how blood clotting proteins bind to membrane surfaces remain poorly understood, owing to a dearth of techniques for studying protein-membrane interactions at high resolution. Our laboratories are tackling this question using a combination of approaches, including nanoscale membrane bilayers, solid-state NMR, and large-scale molecular dynamics simulations. These studies are now providing structural insights at atomic resolution into clotting protein-membrane interactions.

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Conflict of interest statement

Conflicts of interest statement

J.H.M. is a coinventor on patents covering some of the technologies mentioned in this article.

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