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. 2009:2009:754810.
doi: 10.1155/2009/754810. Epub 2009 Jan 25.

On the toxicity of therapeutically used nanoparticles: an overview

A El-Ansary  1 , S Al-Daihan
Affiliations

On the toxicity of therapeutically used nanoparticles: an overview

A El-Ansary et al. J Toxicol. 2009.

Abstract

Human beings have been exposed to airborne nanosized particles throughout their evolutionary stages, and such exposures have increased dramatically over the last century. The rapidly developing field of nanotechnology will result in new sources of this exposure, through inhalation, ingestion, and injection. Although nanomaterials are currently being widely used in modern technology, there is a serious lack of information concerning the human health and environmental implications of manufactured nanomaterials. Since these are relatively new particles, it is necessary to investigate their toxicological behavior. The objective of this review was to trace the cellular response to nanosized particle exposure. Therapeutic application of selected nanoparticles together with their range of toxic doses was also reviewed. Effect of therapeutically used nanoparticles on cell membrane, mitochondrial function, prooxidant/antioxidant status, enzyme leakage, DNA, and other biochemical endpoints was elucidated. This paper highlights the need for caution during the use and disposal of such manufactured nanomaterials to prevent unintended environmental impacts.

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Figures

Figure 1
Figure 1
(a) Number of intracellular contacts and (b) formation of neuritis in nano-Fe2O3 treated PC12 nerve cells.
Figure 2
Figure 2
Mechanism of metabolic alkalosis induced by nanocopper ion.
Figure 3
Figure 3
A summary of the most important recorded toxic effects of therapeutically used nanoparticles reviewed in the present paper.
See this image and copyright information in PMC

References

    1. Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicology in Vitro. 2005;19(7):975–983. - PubMed
    1. Zhang S, Bian Z, Gu C, et al. Preparation of anti-human cardiac troponin I immunomagnetic nanoparticles and biological activity assays. Colloids and Surfaces B: Biointerfaces. 2007;55(2):143–148. - PubMed
    1. Oberdörster G, Oberdörster E, Oberdörster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environmental Health Perspectives. 2005;113(7):823–839. - PMC - PubMed
    1. Oberdörster G, Stone V, Donaldson K. Toxicology of nanoparticles: a historical perspective. Nanotoxicology. 2007;1(1):2–25.
    1. Rayman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA. Variables infleuncing interactions of uncharged quantum dot nanoparticles with skin cells and identification of biochemical modulators. Nano Letters. 2007;7(5):1344–1348. - PubMed

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