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. 2009:2009:765813.
doi: 10.1155/2009/765813. Epub 2009 Apr 6.

Adhesion of respiratory-infection-associated microorganisms on degradable thermoplastic composites

Teemu Tirri  1 , Eva Söderling, Minna Malin, Matti Peltola, Jukka V Seppälä, Timo O Närhi
Affiliations

Adhesion of respiratory-infection-associated microorganisms on degradable thermoplastic composites

Teemu Tirri et al. Int J Biomater. 2009.

Abstract

The purpose of this study was to evaluate bacterial adhesion and early colonization on a composite consisting of bioactive glass (BAG) particles and copolymer of epsilon-caprolactone/D,L-lactide. Materials were incubated with suspensions of both type strains and clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Pseudomonas aeruginosa for 30 minutes (adhesion) and 4 hours (colonization). Clear differences exist in the microorganisms' ability to adhere on the experimental materials. However, the presence of BAG particles does not inhibit bacterial adhesion, but early colonization of the materials with P. aeruginosa was inhibited by the addition of 90-315 mum BAG particles.

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Figures

Figure 1
Figure 1
Attachment of (lg CFU/mL) P. aeruginosa (ATCC 27853), H. influenzae (ATCC 49247), and S. pneumoniae (ATCC 49619) on the experimental materials C, C45, and C90.
Figure 2
Figure 2
Early colonization (lg CFU/mL) by P. aeruginosa (ATCC 27853) and H. influenzae (ATCC 49247) on the experimental materials C, C45, and C90.
Figure 3
Figure 3
SEM image of the P. aeruginosa (ATCC 27853) attachment on the composite (a) and on the C90 disc (b) after 30-minute immersion (white arrows). Bioactive glass granules are visible on the surface of C90 material (black arrows). Images are inverted into negatives to show the attached microbes.
See this image and copyright information in PMC

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