Sildenafil attenuates pulmonary arterial pressure but does not improve oxygenation during ARDS

Abstract

Objective: Pulmonary hypertension is a characteristic feature of acute respiratory distress syndrome (ARDS) and contributes to mortality. Administration of sildenafil in ambulatory patients with pulmonary hypertension improves oxygenation and ameliorates pulmonary hypertension. Our aim was to determine whether sildenafil is beneficial for patients with ARDS.

Design: Prospective, open-label, multicenter, interventional cohort study.

Setting: Medical-surgical ICU of two university hospitals.

Patients: Ten consecutive patients meeting the NAECC criteria for ARDS.

Interventions: A single dose of 50 mg sildenafil citrate administered via a nasogastric tube.

Main results: Administration of sildenafil in patients with ARDS decreased mean pulmonary arterial pressure from 25 to 22 mmHg (P = 0.022) and pulmonary artery occlusion pressure from 16 to 13 mmHg (P = 0.049). Systemic mean arterial pressures were markedly decreased from 81 to 75 mmHg (P = 0.005). Sildenafil did not improve pulmonary arterial oxygen tension, but resulted in a further increase in the shunt fraction.

Conclusion: Although sildenafil reduced pulmonary arterial pressures during ARDS, the increased shunt fraction and decreased arterial oxygenation render it unsuitable for the treatment of patients with ARDS.

Fig. 1

Boxplot of hemodynamic variables during the study period displayed as median, interquartile range (box) and range (whiskers). An asterisk indicates statistically significant change as compared to t = 0 (Wilcoxon signed ranks test)

Fig. 2

Boxplot of shunt fraction during the study period displayed as median, interquartile range (box) and range (whiskers). An asterisk indicates statistically significant change as compared to t = 0 (Wilcoxon signed ranks test)