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Review
. 2010 Mar;15(1):19-33.
doi: 10.1007/s10911-010-9167-z. Epub 2010 Feb 4.

The role of histone modifications and variants in regulating gene expression in breast cancer

Mathieu Dalvai  1 , Kerstin Bystricky
Affiliations
Review

The role of histone modifications and variants in regulating gene expression in breast cancer

Mathieu Dalvai et al. J Mammary Gland Biol Neoplasia. 2010 Mar.

Abstract

The role of epigenetic phenomena in cancer biology is increasingly being recognized. Here we focus on the mechanisms and enzymes involved in regulating histone methylation and acetylation, and the modulation of histone variant expression and deposition. Implications of these epigenetic marks for tumor development, progression and invasiveness are discussed with a particular emphasis on breast cancer progression.

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