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. 2010 Mar;85(3):213-5.
doi: 10.1002/ajh.21608.

Genetic polymorphisms in cytochrome P450s, GSTs, NATs, alcohol consumption and risk of non-Hodgkin lymphoma

Yonghong Li, Tongzhang Zheng, Briseis A Kilfoy, Qing Lan, Theodore Holford, Xuesong Han, Ping Zhao, Min Dai, Brian Leaderer, Nat Rothman, Yawei Zhang

Genetic polymorphisms in cytochrome P450s, GSTs, NATs, alcohol consumption and risk of non-Hodgkin lymphoma

Yonghong Li et al. Am J Hematol. 2010 Mar.

Abstract

The aim of this study was to investigate whether genetic polymorphisms in cytochrome P450s (CYPs), glutathione S-transferases (GSTs), and N-acetyltransferases (NATs) genes modify the relationship between alcohol consumption and risk of non-Hodgkin's lymphoma (NHL) in a population-based, case-control study including 1,115 Connecticut women. Although we did not find strong evidence that the genetic polymorphisms modify the relationship between alcohol consumption and risk of NHL, we identified significant interactions for multiple GSTs and NATs and alcohol intake among persons with DLBCL. Our results confer support investigation of the gene-environment interaction in a larger study population of DLBCL.

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