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. 1991 Apr;83(4):1327-32.
doi: 10.1161/01.cir.83.4.1327.

Fibrocellular tissue response after percutaneous transluminal coronary angioplasty. An immunocytochemical analysis of the cellular composition

M Ueda  1 , A E Becker, T Tsukada, F Numano, T Fujimoto
Affiliations

Fibrocellular tissue response after percutaneous transluminal coronary angioplasty. An immunocytochemical analysis of the cellular composition

M Ueda et al. Circulation. 1991 Apr.

Abstract

Background: Restenosis after initial, successful percutaneous transluminal coronary angioplasty (PTCA) is due to fibrocellular proliferation.

Methods and results: The present study focused on the nature of fibrocellular tissue in humans by use of immunocytochemical techniques. Four hearts (five coronary arteries) were investigated; time lapse between PTCA and death varied between 20 days (two arteries) and 1 year 7 months. Proliferating cells stained positive with smooth muscle cell-specific monoclonal antibodies. Cells from early proliferative lesions (20 days) have a phenotypic expression different from cells in "old" lesions. Proliferating cells stained positive with vimentin but were negative with desmin, irrespective of the lesion's age.

Conclusions: The findings indicate a change in actin isoform expression of smooth muscle cells while adapting to a pathological state.

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