doi: 10.1021/jo902652h.
Domino Heck-aza-Michael reactions: efficient access to 1-substituted tetrahydro-beta-carbolines
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- PMID: 20131765
- DOI: 10.1021/jo902652h
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Domino Heck-aza-Michael reactions: efficient access to 1-substituted tetrahydro-beta-carbolines
J Org Chem.
.
Abstract
A simple and efficient palladium-catalyzed domino reaction for the synthesis of a series of C1-substituted tetrahydro-beta-carbolines is described. This domino process involves a Heck reaction at the indole 2-position of a halogenated tryptamine precursor, followed by intramolecular aza-Michael addition.
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