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. 2010 Mar 5;75(5):1787-90.
doi: 10.1021/jo902652h.

Domino Heck-aza-Michael reactions: efficient access to 1-substituted tetrahydro-beta-carbolines

Daniel L Priebbenow  1 , Luke C Henderson, Frederick M Pfeffer, Scott G Stewart
Affiliations

Domino Heck-aza-Michael reactions: efficient access to 1-substituted tetrahydro-beta-carbolines

Daniel L Priebbenow et al. J Org Chem. .

Abstract

A simple and efficient palladium-catalyzed domino reaction for the synthesis of a series of C1-substituted tetrahydro-beta-carbolines is described. This domino process involves a Heck reaction at the indole 2-position of a halogenated tryptamine precursor, followed by intramolecular aza-Michael addition.

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