Ictal hypoventilation contributes to cardiac arrhythmia and SUDEP: report on two deaths in video-EEG-monitored patients
- PMID: 20132291
- DOI: 10.1111/j.1528-1167.2009.02513.x
Ictal hypoventilation contributes to cardiac arrhythmia and SUDEP: report on two deaths in video-EEG-monitored patients
Abstract
Sudden unexplained death in epilepsy (SUDEP) is a common cause of death in patients with epilepsy, with cardiorespiratory dysfunction and a primary cessation of cerebral function proposed as causes. We report two cases of SUDEP in patients with intractable temporal lobe epilepsy undergoing video-EEG (electroencephalography) telemetry at two centers. Both had secondarily generalized convulsions. EEG, electrocardiography (ECG), and respiratory changes in these two patients are reported herein. Ictal/postictal hypoventilation may contribute to SUDEP with the resulting hypoxemia and acidosis leading to failure of recovery of cortical function and eventual cardiac failure.
Similar articles
-
Ictal apnea linked to contralateral spread of temporal lobe seizures: Intracranial EEG recordings in refractory temporal lobe epilepsy.Epilepsia. 2009 Dec;50(12):2557-62. doi: 10.1111/j.1528-1167.2009.02245.x. Epub 2009 Aug 13. Epilepsia. 2009. PMID: 19682029
-
Ictal hypoxemia in localization-related epilepsy: analysis of incidence, severity and risk factors.Brain. 2008 Dec;131(Pt 12):3239-45. doi: 10.1093/brain/awn277. Epub 2008 Oct 24. Brain. 2008. PMID: 18952672 Free PMC article.
-
Cardiac asystole in epilepsy: clinical and neurophysiologic features.Epilepsia. 2003 Feb;44(2):179-85. doi: 10.1046/j.1528-1157.2003.15101.x. Epilepsia. 2003. PMID: 12558571
-
Respiratory pathophysiology with seizures and implications for sudden unexpected death in epilepsy.J Clin Neurophysiol. 2015 Feb;32(1):10-3. doi: 10.1097/WNP.0000000000000142. J Clin Neurophysiol. 2015. PMID: 25647768 Review.
-
Cardiac arrhythmias and sudden unexpected death in epilepsy (SUDEP).Pacing Clin Electrophysiol. 2012 Mar;35(3):363-70. doi: 10.1111/j.1540-8159.2011.03276.x. Epub 2011 Nov 29. Pacing Clin Electrophysiol. 2012. PMID: 22126214 Review.
Cited by
-
Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP.Epilepsy Curr. 2021 Mar 31;21(3):15357597211004556. doi: 10.1177/15357597211004556. Online ahead of print. Epilepsy Curr. 2021. PMID: 33787378 Free PMC article.
-
Evidence for brainstem network disruption in temporal lobe epilepsy and sudden unexplained death in epilepsy.Neuroimage Clin. 2014 Jul 9;5:208-16. doi: 10.1016/j.nicl.2014.06.010. eCollection 2014. Neuroimage Clin. 2014. PMID: 25068110 Free PMC article.
-
SUDEP: What Are the Risk Factors? Do Seizures or Antiepileptic Drugs Contribute to an Increased Risk?Epilepsy Curr. 2012 Jul;12(4):131-2. doi: 10.5698/1535-7511-12.4.131. Epilepsy Curr. 2012. PMID: 22936881 Free PMC article. No abstract available.
-
Seizures, Cerebral Shutdown, and SUDEP.Epilepsy Curr. 2013 Sep;13(5):236-40. doi: 10.5698/1535-7597-13.5.236. Epilepsy Curr. 2013. PMID: 24348118 Free PMC article.
-
Electrocardiographic changes in patients with refractory epilepsy.J Res Med Sci. 2013 Mar;18(Suppl 1):S32-4. J Res Med Sci. 2013. PMID: 23961281 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources