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Comment
. 2010 Feb 5;327(5966):653-4.
doi: 10.1126/science.1186121.

Biochemistry. An ensemble view of allostery

Vincent J Hilser  1
Affiliations
Comment

Biochemistry. An ensemble view of allostery

Vincent J Hilser. Science. .
No abstract available

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Figures

Figure
Figure. The ensemble model of allostery reveals the energetic basis of coupling
The ensemble for a protein with an effector (I) and a functional (II) subunit is shown (A) before and (B) after activation with an effector ligand (blue circle). Prior to activation, the most probable state has an inactive functional subunit (II with black circle). Stabilization of the active conformation of the effector subunit (blue arrows) populates the active conformation of the functional subunit (II with red star).
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