Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast
- PMID: 20133720
- PMCID: PMC2840419
- DOI: 10.1073/pnas.0911177107
Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast
Abstract
Recent advances in high-field MRI have dramatically improved the visualization of human brain anatomy in vivo. Most notably, in cortical gray matter, strong contrast variations have been observed that appear to reflect the local laminar architecture. This contrast has been attributed to subtle variations in the magnetic properties of brain tissue, possibly reflecting varying iron and myelin content. To establish the origin of this contrast, MRI data from postmortem brain samples were compared with electron microscopy and histological staining for iron and myelin. The results show that iron is distributed over laminae in a pattern that is suggestive of each region's myeloarchitecture and forms the dominant source of the observed MRI contrast.
Conflict of interest statement
The authors declare no conflict of interest.
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References
-
- Raichle ME. Measurement of local cerebral blood flow and metabolism in man with positron emission tomography. Fed Proc. 1981;40:2331–2334. - PubMed
-
- Brodmann K. Vergleichende Lokalisationlehre der Grosshirnrinde. Leipzig, Germany: Johann Ambrosius Barth Verlag; 1909.
-
- Vogt O. Die Myeloarchitektonik des Isocortex parietalis. J Psychol Neurol. 1911;15:221–232.
-
- Wong-Riley MT, et al. Cytochrome oxidase in the human visual cortex: distribution in the developing and the adult brain. Vis Neurosci. 1993;10:41–58. - PubMed
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