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Comment

. 2010 Jan 26;107(4):1263-4.

doi: 10.1073/pnas.0913922107.

Excess betaCTF, not Abeta: the culprit in Alzheimer-related endocytic dysfunction

W Sue T Griffin¹

Affiliations

Affiliation

¹ Donald W. Reynolds Department of Geriatrics and Institute on Aging, University of Arkansas for Medical Sciences, and the GRECC at the Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA. griffinsuet@uams.edu

PMID: 20133888
PMCID: PMC2824414
DOI: 10.1073/pnas.0913922107

Comment

Excess betaCTF, not Abeta: the culprit in Alzheimer-related endocytic dysfunction

W Sue T Griffin. Proc Natl Acad Sci U S A. 2010.

. 2010 Jan 26;107(4):1263-4.

doi: 10.1073/pnas.0913922107.

Author

W Sue T Griffin¹

Affiliation

¹ Donald W. Reynolds Department of Geriatrics and Institute on Aging, University of Arkansas for Medical Sciences, and the GRECC at the Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA. griffinsuet@uams.edu

PMID: 20133888
PMCID: PMC2824414
DOI: 10.1073/pnas.0913922107

No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Comment on

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.
Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, Nixon RA. Jiang Y, et al. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1630-5. doi: 10.1073/pnas.0908953107. Epub 2009 Dec 28. Proc Natl Acad Sci U S A. 2010. PMID: 20080541 Free PMC article.

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References

1. Jiang Y, et al. Alzheimer’s-related endosome dysfunction in Down syndrome is Aβ-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci USA. 2009;107:1630–1635. - PMC - PubMed
1. Griffin WS, et al. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci USA. 1989;86:7611–7615. - PMC - PubMed
1. Tanzi RE, et al. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer’s disease. Nature. 1988;331:528–530. - PubMed
1. Mrak RE, Griffin WS. Glia and their cytokines in progression of neurodegeneration. Neurobiol Aging. 2005;26:349–354. - PubMed
1. Barger SW, Harmon AD. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature. 1997;388:878–881. - PubMed

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