Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes
- PMID: 20134026
- PMCID: PMC3023998
- DOI: 10.1152/physiol.00039.2009
Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes
Abstract
The voltage-gated proton channel bears surprising resemblance to the voltage-sensing domain (S1-S4) of other voltage-gated ion channels but is a dimer with two conduction pathways. The proton channel seems designed for efficient proton extrusion from cells. In phagocytes, it facilitates the production of reactive oxygen species by NADPH oxidase.
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