Excitability and rhythmicity of tracheobronchial cough is altered by aspiration reflex in cats

Abstract

Effects of nasopharyngeal stimulation on excitability and rhythmicity of mechanically induced tracheobronchial cough were examined on 18 pentobarbitone anesthetized cats. After the 17.2+/-2.4 aspiration reflexes (AspRs), tracheobronchial stimulation evoked lower number of coughs (P<0.05) with longer latency to the diaphragm activation (P<0.02), compared to control. AspRs induced within "inter-cough" periods (motor quiescence between individual coughs; 3.3 AspRs per period) reduced cough number by 50% (P<0.01), shortened cough-related abdominal activity (P<0.02), prolonged inter-cough period (P<0.02), and the total cough cycle duration (P<0.05). Cough efforts occurred irregularly with very variable "inter-cough" distances and total cough cycle durations. The subthreshold nasopharyngeal stimulation (failing to evoke AspR) did not affect rhythmic coughing. AspRs induced during persisting post-stimulation coughs did not significantly reduce their number. Excitability and rhythmicity of mechanically induced tracheobronchial cough can be reduced by AspRs, but not by subthreshold nasopharyngeal stimulation. The suppressive effect of spasmodic inspirations on chronic cough is suggested.