Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Feb;12(1):81-6.
doi: 10.1007/BF02337618.

HLA antigens in Italian multiple sclerosis patients

L La Mantia  1 , M T Illeni, C Milanese, A Salmaggi, M Eoli, G Pellegris, A Nespolo
Affiliations

HLA antigens in Italian multiple sclerosis patients

L La Mantia et al. Ital J Neurol Sci. 1991 Feb.

Abstract

We analyzed HLA-A, -C, -B, -DR and -DQ specificities in 104 Italian multiple sclerosis patients and in 905 healthy controls. The frequencies of HLA-A23, A26, Cw4, DR3 and, especially DR5 antigens were significantly higher in multiple sclerosis patients than in controls. Patients with progressive course were characterized by high frequencies of B7, B8 and DR3 antigens: Cw1 and DRw11 shows a negative correlation with the extent of intrathecal IgG production. These data confirm that the HLA system may influence the clinical expression and the immune responses to the disease.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Ann Hum Genet. 1955 Jun;19(4):251-3 - PubMed
    1. Indian J Med Res. 1986 May;83:519-21 - PubMed
    1. Lancet. 1981 Jul 11;2(8237):98 - PubMed
    1. Br Med Bull. 1977 Jan;33(1):4-9 - PubMed
    1. J Immunol. 1985 Mar;134(3):1551-4 - PubMed

LinkOut - more resources