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. 1991 Feb;12(1):81-6.
doi: 10.1007/BF02337618.

HLA antigens in Italian multiple sclerosis patients

L La Mantia  1 , M T Illeni, C Milanese, A Salmaggi, M Eoli, G Pellegris, A Nespolo
Affiliations

HLA antigens in Italian multiple sclerosis patients

L La Mantia et al. Ital J Neurol Sci. 1991 Feb.

Abstract

We analyzed HLA-A, -C, -B, -DR and -DQ specificities in 104 Italian multiple sclerosis patients and in 905 healthy controls. The frequencies of HLA-A23, A26, Cw4, DR3 and, especially DR5 antigens were significantly higher in multiple sclerosis patients than in controls. Patients with progressive course were characterized by high frequencies of B7, B8 and DR3 antigens: Cw1 and DRw11 shows a negative correlation with the extent of intrathecal IgG production. These data confirm that the HLA system may influence the clinical expression and the immune responses to the disease.

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