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Meta-Analysis
. 2010 Feb 14;16(6):770-7.
doi: 10.3748/wjg.v16.i6.770.

Treatment of hepatitis B virus-associated glomerulonephritis: a meta-analysis

Yu Zhang  1 , Jian-Hua Zhou, Xiao-Ling Yin, Feng-Yu Wang
Affiliations
Meta-Analysis

Treatment of hepatitis B virus-associated glomerulonephritis: a meta-analysis

Yu Zhang et al. World J Gastroenterol. .

Abstract

Aim: To evaluate the efficacy of antiviral or corticosteroid treatment on hepatitis B virus-associated glomerulonephritis (HBV-GN).

Methods: Six and five trials were used respectively to evaluate the efficacy of either antiviral or corticosteroid treatment on HBV-GN. Pediatric patients were pooled separately to assess their response to the above treatment modalities. The primary and secondary outcomes were remission of proteinuria and clearance of Hepatitis B e-antigen (HBeAg), respectively. A fixed or random effect model was established to collect the data.

Results: The remission rate of proteinuria (RR = 1.69, 95% CI: 1.08-2.65) and the clearance rate of HBeAg (RR = 6.44, 95% CI: 3.11-13.35) were significantly higher in antiviral treatment group than in control group. The proteinuria remission was significantly associated with HBeAg clearance (P = 0.002). However, the difference in proteinuria remission rate was not statistically significant between corticosteroid treatment group and control group (RR = 1.45, 95% CI: 0.68-3.11). Antiviral therapy could significantly promote the HBeAg clearance in pediatric patients, but neither antiviral nor corticosteroid therapy could significantly decrease proteinuria in pediatric patients compared to controls.

Conclusion: Antiviral but not corticosteroid treatment can decrease proteinuria and promote HBeAg clearance in HBV-GN patients.

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Figures

Figure 1
Figure 1
Proteinuria remission rate in antiviral treatment group and control group (A, B) and in pediatric patients (C).
Figure 2
Figure 2
Clearance rate of HBeAg in antiviral treatment group and control group (A) and in pediatric patients (B).
Figure 3
Figure 3
Proteinuria remission rate in corticosteroid treatment group and control group (A) and in pediatric patients (B).
Figure 4
Figure 4
Funnel plots for 6 articles in meta-analysis of clinical response to antiviral therapy (A), 6 articles in meta-analysis of virologic response to antiviral therapy (B), and 5 articles in meta-analysis of clinical response to corticosteroid treatment (C).
See this image and copyright information in PMC

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