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. 2010 Apr;40(5):515-9.
doi: 10.1016/j.ijpara.2010.01.006. Epub 2010 Feb 4.

Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon

Emmanuel Assana  1 , Craig T Kyngdon, Charles G Gauci, Stanny Geerts, Pierre Dorny, Redgi De Deken, Garry A Anderson, André P Zoli, Marshall W Lightowlers
Affiliations

Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon

Emmanuel Assana et al. Int J Parasitol. 2010 Apr.

Abstract

A pilot field trial of the TSOL18 vaccine was undertaken in Cameroon. Two hundred and forty, 2-3 month-old piglets were distributed to 114 individual households in pairs. Vaccinated animals received three immunisations with 200 microg TSOL18 plus 5 mg Quil A and 30 mg/kg oxfendazole at the time of the second immunisation. Necropsies were undertaken when the pigs were approximately 12 months of age. Viable Taenia solium cysticerci were identified in 20 control pigs (prevalence 19.6%); no cysticerci were found in any of the vaccinated animals (P<0.0001). Combined application of TSOL18 vaccination and a single oxfendazole treatment in pigs may be a relatively simple and sustainable procedure that has the potential to control T. solium transmission in endemic areas and, indirectly, reduce the number of new cases of neurocysticercosis in humans.

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Figures

None
Graphical abstract
Fig. 1
Fig. 1
Location of the villages in the Mayo-Danay district of far north Cameroon in which host farms were located and pigs were kept during the field trial of the TSOL18 vaccine against Taenia solium infection.
Fig. 2
Fig. 2
Anti-TSOL18 antibody titres (geometric mean ± S.D.) in vaccinated pigs following immunisation with TSOL18. Pigs received three immunisations and serum samples obtained prior to the first immunisation (PB) and 2 weeks after each immunisation (2wpV1, 2wpV2, 2wpV3) as well as at the time of necropsy (Nec). Antibody titres were determined against recombinant TSOL18 expressed as a maltose binding protein fusion with sera serially diluted from 1:100 and the titre calculated as the dilution at which the O.D. in ELISA equalled 0.5.
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References

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