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. 2010 Mar;13(3):281-3.
doi: 10.1038/nn.2494. Epub 2010 Feb 7.

Bimodal control of stimulated food intake by the endocannabinoid system

Luigi Bellocchio  1 , Pauline Lafenêtre, Astrid Cannich, Daniela Cota, Nagore Puente, Pedro Grandes, Francis Chaouloff, Pier Vincenzo Piazza, Giovanni Marsicano
Affiliations

Bimodal control of stimulated food intake by the endocannabinoid system

Luigi Bellocchio et al. Nat Neurosci. 2010 Mar.

Abstract

Activation of cannabinoid type-1 receptors (CB(1)) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood. Using combined genetic and pharmacological approaches in mice, we found that ventral striatal CB(1) receptors exerted a hypophagic action through inhibition of GABAergic transmission. Conversely, brain CB(1) receptors modulating excitatory transmission mediated the well-known orexigenic effects of cannabinoids.

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