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. 2009 Oct;34(10):554-64.

Erlotinib (tarceva) for the treatment of non-small-cell lung cancer and pancreatic cancer

Caio M Rocha-Lima, Luis E Raez

Erlotinib (tarceva) for the treatment of non-small-cell lung cancer and pancreatic cancer

Caio M Rocha-Lima et al. P T. 2009 Oct.

Abstract

Erlotinib (Tarceva) is a small-molecule, orally dosed, anti-cancer drug that inhibits the epidermal growth factor receptor. Randomized, controlled clinical studies have demonstrated that erlotinib significantly improved survival in patients with previously treated non-small-cell lung cancer and, in combination with chemotherapy, in patients with untreated pancreatic cancer. In this article, we describe the clinical evidence and value of erlotinib as a therapy for non-small-cell lung cancer and pancreatic cancer and discuss ongoing clinical studies to optimize its use in various settings and to identify appropriate patient populations.

Keywords: EGFR mutation; erlotinib; non-small-cell lung cancer; pancreatic cancer.

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