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Review
. 2009 Jun;29(3):119-26.

Human Papilloma Virus (HPV) in head and neck region: review of literature

L Mannarini  1 , V Kratochvil, L Calabrese, L Gomes Silva, P Morbini, J Betka, M Benazzo
Affiliations
Review

Human Papilloma Virus (HPV) in head and neck region: review of literature

L Mannarini et al. Acta Otorhinolaryngol Ital. 2009 Jun.

Abstract
in English, Italian

The evidence that human papillomavirus infection is related to head and neck squamous cell carcinoma is supported by molecular and epidemiological data. The definition of a distinct subset of head and neck squamous cell carcinoma, independent of the traditional risk factors and with different clinical presentation and outcome, has led to increasing interest in human papillomavirus infection. This review summarizes current knowledge regarding human papillomavirus biology, oncogenic mechanisms, risk factors for transmission, clinical significance and prophylactic strategies.

Dati molecolari ed epidemiologici sostengono una correlazione tra infezione da papilloma virus umano (HPV) e carcinomi squamocellulari del distretto cervico facciale (HNSCC). La definizione di un sottogruppo di HNSCC, indipendente dai tradizionali fattori di rischio e con caratteristiche cliniche e prognostiche differenti, ha portato ad avere un interesse sempre maggiore nell’infezione da HPV. Questa review riassume le conoscenze attuali sulle caratteristiche biologiche, i meccanismi oncogenetici, i fattori di rischio per la trasmissione ed il significato clinico e terapeutico dell’infezione da HPV.

Keywords: Head and neck; Human papillomavirus; Oral cavity; Oropharynx; Squamous cell carcinoma.

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