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. 2010 Mar 5;75(5):1791-4.
doi: 10.1021/jo9026935.

Cu-catalyzed arylation of phenols: synthesis of sterically hindered and heteroaryl diaryl ethers

Debabrata Maiti  1 , Stephen L Buchwald
Affiliations

Cu-catalyzed arylation of phenols: synthesis of sterically hindered and heteroaryl diaryl ethers

Debabrata Maiti et al. J Org Chem. .

Abstract

Cu-catalyzed O-arylation of phenols with aryl iodides and bromides can be performed under mild condition in DMSO/K(3)PO(4) with use of picolinic acid as the ligand for copper. This method tolerates a variety of functional groups and is effective in the synthesis of hindered diaryl ethers and heteroaryl ethers.

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Figures

Scheme 1
Scheme 1
Selected biologically active diaryl ethers
See this image and copyright information in PMC

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