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. 1991 Apr 15;88(8):3412-5.
doi: 10.1073/pnas.88.8.3412.

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells

R J Rotello  1 , R C Lieberman, A F Purchio, L E Gerschenson
Affiliations

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells

R J Rotello et al. Proc Natl Acad Sci U S A. .

Abstract

Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.

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